P6 - Body Weight Homeostasis Physiopathology

Introduction

This programme, in continuation of its work in the previous two years, seeks to implement multidisciplinary studies in various pre-clinical and clinical models of energy homeostasis disturbance as the basis for generating physiological knowledge (about mechanisms for controlling energy balance and related bodily functions) and pathological knowledge (relating to disorders in overweight conditions) that can be transferred to clinical practice for obesity and its associated co-morbidities.

Activities will allow implementing studies aimed at identifying new etiopathogenic mechanisms and therapeutic targets with translational potential in the field of obesity and its complications, essentially by means of studying pre-clinical models. It should be pointed out that the nutritional and pharmacological armamentarium that is available for the treatment of obesity is quite scarce, and the current panorama could even be described as bleak. The potential of different inter- and intracellular signalling systems determining energy homeostasis will be studied in order to assess their use as a therapeutic target against obesity. A strategy that contemplates identifying new signals involved in controlling the energy intake and expenditure, acting both centrally and on peripheral tissues that are particularly relevant on a metabolic level, such as the liver, muscle and adipose tissues, has been designed for this purpose.

In addition, emphasis is placed on establishing interactions of the body weight control mechanisms and their dysfunction with biological determinants (sex, reproductive processes) by means of pre-clinical experimental models.

The identification of new agonists/antagonists of different hormonal and/or adipokine signals affecting body weight homeostasis, inflammation, lipid metabolism or cardiovascular and hepatic disorders associated with obesity can lead to an actual improvement in the health prospects of obese patients.

General Objective

To establish biological factors and intra- and inter-cellular signalling controlling body weight homeostasis, as well as disorders in these processes occurring with obesity.

Attached Groups

Main ResearcherConsortium InstitutionRegionsDetails
Diéguez González, Carlos Universidad de Santiago de Compostela Galicia View group
Argente Oliver, Jesús Servicio Madrileño de Salud Madrid View group
Casanueva Freijo, Felipe Servicio Gallego de Salud Galicia View group
Remesar Betlloch, Xavier Universidad de Barcelona Cataluña View group
Villarroya Gombau, Francesc Universidad de Barcelona Cataluña View group
Tena Sempere, Manuel Universidad de Córdoba Andalucía View group
Frühbeck Martínez, Gema Universidad de Navarra Navarra View group
Lasunción Ripa, Miguel Ángel Servicio Madrileño de Salud Madrid View group
Osada García, Jesús de la Universidad de Zaragoza Aragón View group
Palou Oliver, Andreu Universidad de las Islas Baleares Islas Baleares View group